In recent years, two technologies – mixed-mode chromatography and core-shell particles – emerged and gained popularity as tools offering new selectivity and speed for analysis of complex mixtures. Mixed-mode chromatography offers a unique alternative selectivity which cannot be matched by reversed-phase or HILIC columns.

Core-shell technology offers the unique ability to achieve high efficiency at higher flow rates whilst generating back pressures that can be achieved using traditional HPLC systems. This offers the end user the opportunity to improve separation speed and quality without the requirement to purchase UPLC equipment. We have recognized the exciting opportunities afforded by combining these two great technologies in stationary phases to achieve unique selectivity and high efficiency with traditional HPLC systems that are rated to 4000 or 6000 psi.

Mixed-mode columns offer much higher capacity and retention than traditional reversed-phase columns. Since the surface area of core-shell particles is reduced, mixed-mode phases address potential loadability issues while maintaining the selectivity advantages of multiple interactions. Newly optimized ligand density and ionic/hydrophobic ratios further increase the capacity of mixed-mode core-shell columns.

 

We are offering three mixed-mode core-shell columns:

Coresep 100 is a reverse-phase analytical column with embedded acidic ion-pairing groups embedded on core-shell particles.

  • Improves retention of basic compounds by cation-exchange mechanism.
  • Separates acids by ion-exclusion mechanism.
  • Retains neutral compounds by reverse-phase mechanism.
  • All mobile phases are LC-MS and preparative chromatography compatible

Coresep S is a normal-phase analytical column with embedded acidic ion-pairing groups embedded on core-shell particles.

  • Most suitable for separation of common sugars and other neutral or very polar molecules.
  • Retains and separates compounds based on HILIC, cation-exchange and anion-exclusion modes
  • Retains and separates amino acids with different buffers at low concentration.
  • Separates weak bases by ion-exchange mechanism.
  • Separate acids by ion-exclusion mechanism.
  • All mobile phases are LC-MS and preparative chromatography compatible (working pH range from 2.0 to 7.0).

Coresep SB is a reverse-phase analytical column with strong embedded basic ion-pairing groups embedded on core-shell particles.

  • Improves retention of acidic compounds by anion-exchange mechanism.
  • Separates bases by ion-exclusion mechanism.
  • Retains neutral compounds by reverse-phase mechanism.
  • All mobile phases are LC-MS and preparative chromatography compatible (working pH range from 1.5 to 5).

 

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