Application description
Cocaine is a powerful and highly addictive stimulant. Cocaine is a Schedule II controlled substance. Cocaine is the second most frequently used drug. It is hydrophobic and basic in nature. We have analyzed cocaine and related impurity on core-shell Coresep 100 mixed-mode column in reversed-phase cation-exchange modes. Core-shell mixed-mode chromatography offers a synergy of unique selectivity of mixed-mode stationary phases and high efficiency of core-shell particles. The method can be used for analysis of cocaine and other illegal drugs in various sample matrices. This method is compatible with major detection techniques including mass spectrometry.
Conditions of Experiment
| Column: |
Coresep 100 |
| Separation Modes: |
reversed-phase and cation-exchange |
| Column Dimenstions: |
3.0 x 100 mm |
| Mobile Phase: |
60% ACN with 30 mM AmFm pH 3 |
| Detection: |
UV 275 nm |
| Sample: |
0.3 mg/ml |
| Injection: |
1 uL |
| Flow rate: |
0.8 mL/min |
Analytes
| Class of compounds: |
Aromatic acid, Aromatic base, Controlled substance, Drug, Illegal drug |
| Nature of compounds: |
Basic, Hydrophilic, Hydrophobic |
| Compounds: |
Cocaine, Related Impurities |
