HPLC Analysis of Drug Escitalopram on Coresep 100 Mixed-Mode Column

HPLC Analysis of Drug Escitalopram on Coresep 100 Mixed-Mode Column chromatogram
Conditions of Experiment
Column:
Coresep 100
Separation Modes:
reversed-phase and cation-exchange
Column Dimenstions: 3.0 x 100 mm
Mobile Phase: 65% ACN with 0.1% of H3PO4
Detection: UV 215 nm
Sample: 0.3 mg/ml
Injection: 1 uL
Flow rate: 0.6 mL/min
Analytes
1. Escitalopram

Class of compounds: Drug
Nature of compounds: Basic, Hydrophobic

Application description

Escilatopram is an antidepressant medication mainly used to treat major depressive disorders. Escilatopram is a selective serotonin reuptake inhibitor. The compound is hydrophobic and basic in nature. HPLC method was developed for HPLC analysis of Escitalopram on Coresep 100 mixed-mode column. The method is robust with good peak shape for main compound. This method can be used for analysis of hydrophobic basic compounds in reversed-phase cation-exchange mode. Retention time is controlled by amount of ACN, buffer concentration and buffer pH. Method is fast, robust, reproducible, and can be used for analysis of escitalopram in various samples. Various mobile phases can be used with Coresep 100 column to accommodate different detection techniques (UV, MS, CAD, ELSD detection). Core-shell mixed-mode columns provide a great combination of unique selectivity, speed, and efficiency.

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