HPLC Analysis of Drug Torbutrol on Coresep 100 Mixed-Mode Column

HPLC Analysis of Drug Torbutrol on Coresep 100 Mixed-Mode Column chromatogram
Conditions of Experiment
Coresep 100
Separation Modes:
reversed-phase and cation-exchange
Column Dimenstions: 3.0 x 100 mm
Mobile Phase: 65% ACN with 0.1% of H3PO4
Detection: UV 215 nm
Sample: 0.3 mg/ml
Injection: 1 uL
Flow rate: 0.6 mL/min
1. Torbutrol
2. Related Impurities

Class of compounds: Aromatic acid, Aromatic base, Controlled substance, Drug
Nature of compounds: Basic, Hydrophilic, Hydrophobic

Application description

Torbutrol is a morphine type synthetic opioid analgesic. Torbutrol is used in migraine pain management. Compound is hydrophobic and basic in nature. Torbutrol was analyzed on Coresep 100 mixed-mode core-shell column in RP/cation-exchange mode. Retention time is controlled by amount of ACN, buffer concentration and buffer pH. Method is fast, robust, reproducible, and can be used for analysis of torbutrol in various sample matrices. Various mobile phases can be used with Coresep 100 column to accommodate different detection techniques (UV, MS, CAD, ELSD detection). Core-shell mixed-mode columns provide a great combination of unique selectivity, speed, and efficiency.

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