HPLC Analysis of N-Nitrosodiethylamine in Valsartan Drug Formulation on Coresep SB Mixed-Mode Columns

Conditions of Experiment
Column: Coresep SB
Separation Modes: reversed-phase
Column Dimenstions: 4.6x150 mm, 2.7 um, 90A
Mobile Phase: ACN gradinet from 15% to 85% in 10 min, 5 min hold. 0.1% phosphoric acid
Detection: UV 230 nm
Sample: 1 mg/ml
Injection: 3 uL
Flow rate: 1 ml/min
Analytes
Class of compounds: Drug, Organic compound
Nature of compounds: Acidic, Hydrophilic, Hydrophobic, Neutral, Polar
Compounds: N-Nitrosodiethylamine, Valsartan