Acetaminophen
Applications
HPLC Analysis of Drug Composition on Heritage C18 Column According to US Pharmacopeia
| Conditions of Experiment | ||||||||||||||||
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| Analytes |
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1. Acetaminophen 2. Caffeine 3. Aspirin 4. Benzoic acid 5. Salicylic acid |
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Class of compounds: Aromatic acid, Aromatic compound, Drug, Organic acid, Stimulant, Xanthine |
| Nature of compounds: Acidic, Hydrophilic, Hydrophobic, Neutral, Polar |
Application description
HPLC Analysis of Drug Norco on Heritage MA Mixed-Mode Column
| Conditions of Experiment | ||||||||||||||||
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| Analytes |
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1. Hydrocodone 2. Acetaminophen |
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Class of compounds: Aromatic base, Aromatic compound, Controlled substance, Drug |
| Nature of compounds: Basic, Hydrophilic, Hydrophobic, Neutral |
Application description
Hydrocodone/paracetamol, also known as hydrocodone/acetaminophen or hydrocodone/APAP is the combination of an opioid pain medication, hydrocodone, with paracetamol (acetaminophen). It is used as a prescription drug to relieve moderate to severe pain. It exists in tablet, elixir, and solution forms in various strengths for oral administration. Vicodin is Schedule II controlled substance. Hydrocodone diversion and recreational use has escalated in recent years due to its opioid effects. Norco was analyzed with isocratic conditions to provide fast, reliable and robust method for analysis of both components of the drug combination - hydrocodone and acetaminophen. Compounds are retained and separated on Heritage MA HPLC column in reversed-phase and cation-exclusion mechanisms. Retention time, selectivity, and resolution between peaks can be adjusted by modification of amount of ACN, buffer and buffer pH. Various mobile phases can be used with Heritage MA column to accommodate different detection techniques (UV, MS, CAD, ELSD detection).
HPLC Analysis of Drug Vicodin on Heritage MA Mixed-Mode Column
| Conditions of Experiment | ||||||||||||||||
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| Analytes |
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1. Codeine 2. Acetaminophen |
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Class of compounds: Aromatic base, Aromatic compound, Controlled substance, Drug |
| Nature of compounds: Basic, Hydrophilic, Hydrophobic, Neutral |
Application description
Codeine/paracetamol, also known as codeine/acetaminophen or hydrocodone/APAP is the combination of an opioid pain medication, codeine, with paracetamol (acetaminophen). It is used as a prescription drug to relieve moderate to severe pain. It exists in tablet, elixir, and solution forms in various strengths for oral administration. Vicodin is Schedule II controlled substance. Codeine diversion and recreational use has escalated in recent years due to its opioid effects. Vicodin was analyzed with isocratic conditions to provide fast, reliable and robust method for analysis of both components of the drug combination - codeine and acetaminophen. Compounds are retained and separated on Heritage MA HPLC column in reversed-phase and cation-exclusion mechanisms. Retention time, selectivity and resolution between peaks can be adjusted by modification of amount of ACN, buffer and buffer pH. Various mobile phases can be used with Coresep 100 column to accommodate different detection techniques (UV, MS, CAD, ELSD detection).
Fast HPLC Analysis of Drug Composition on Coresep 100 Mixed-Mode Core-Shell Column
| Conditions of Experiment | ||||||||||||||||
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| Analytes |
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1. Phenylalanine 2. Acetaminophen 3. Guaifenesin 4. Guaiacol |
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Class of compounds: Amino acid, Aromatic compound, Drug, Supplement |
| Nature of compounds: Hydrophilic, Neutral, Polar, Zwitterionic |
Application description
Selectivity Difference for Polar Compounds in Reversed-Phase and Mixed-Mode Separation on Coresep 100 HPLC Column
| Conditions of Experiment | ||||||||||||||||
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| Analytes |
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1. Acetaminophen 2. Caffeine 3. Benzoic acid |
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Class of compounds: Aromatic acid, Aromatic compound, Drug, Organic acid, Stimulant, Xanthine |
| Nature of compounds: Acidic, Hydrophilic, Neutral |
Application description
Core-shell mixed-mode columns offer unique selectivity which comes from the presence of two mechanisms - reversed-phase and ion-exchange. The alternative selectivity of mixed-mode columns can be used when order of elution or resolution between compounds needs improvement. Even for neutral compounds a different selectivity can be obtained. A method for common components of headache medications (acetaminophen, caffeine, and benzoate) was developed on our Coresep 100 column. Efficiency and peak shape are comparable to leading brand core-shell reversed-phase columns.