Cocaine

Cocaine C17H21NO4

Cocaine

Applications

HPLC Separation of Controlled Substances on Coresep 100 Mixed-Mode Column

HPLC Separation of Controlled Substances on Coresep 100 Mixed-Mode Column chromatogram
Conditions of Experiment
Column:
Coresep 100
Separation Modes:
hydrogen-bonding and cation-exchange
Column Dimenstions: 3.0 x 100 mm
Mobile Phase: ACN gradient from 50% to 80%, AmFm pH 3 from 20 mM to 40 mM in 10 min
Detection: UV 275 nm
Sample: 0.3 mg/ml
Injection: 1 uL
Flow rate: 1 mL/min
Analytes
1. Morphine
2. Codeine
3. Oxycodone
4. Cocaine
5. Hydrocodone

Class of compounds: Aromatic base, Controlled substance, Drug, Illegal drug
Nature of compounds: Basic, Hydrophobic

Application description

Morphine is an opiate which is used as pain medication. It is Schedule II controlled substance. Codeine is an opiate medication used as effective pain drug as well as a component of cough medications. Codeine is Schedule II controlled substance. Oxycodone is opioid pain medication. It is Schedule II controlled substance. Cocaine is a strong stimulant mostly used as recreational drug. It is Schedule II controlled substance. Hydrocodone is an opioid derived from codeine and one of the opioid alkaloids in opium poppy. It is a narcotic analgesic. Hydrocodone is used to treat moderate to severe pain. It is Schedule II controlled substance. Analysis of drugs of abuse and controlled substances is an important task. All 5 compounds are hydrophobic and basic in nature, thye retain on Coresep 100 column by combination of reversed-phase and cation-exchange mechanisms. Amount of ACN, buffer pH and buffer concentration can be used to adjust retention time and selectivity of this separation. The method can be used for analysis of illegal drugs and controlled substances in formulations and biofluids. The method is fully compatible with mass spectrometry. Core-shell mixed-mode columns offer combination of unique selectivity and high efficiency while using regular equipment.

HPLC Analysis of Illicit Drug Cocaine and Related Impurities on Coresep 100 Mixed-Mode Column

HPLC Analysis of Illicit Drug Cocaine and Related Impurities on Coresep 100 Mixed-Mode Column chromatogram
Conditions of Experiment
Column:
Coresep 100
Separation Modes:
reversed-phase and cation-exchange
Column Dimenstions: 3.0 x 100 mm
Mobile Phase: 60% ACN with 30 mM AmFm pH 3
Detection: UV 275 nm
Sample: 0.3 mg/ml
Injection: 1 uL
Flow rate: 0.8 mL/min
Analytes
1. Cocaine
2. Related Impurities

Class of compounds: Aromatic acid, Aromatic base, Controlled substance, Drug, Illegal drug
Nature of compounds: Basic, Hydrophilic, Hydrophobic

Application description

Cocaine is a powerful and highly addictive stimulant. Cocaine is a Schedule II controlled substance. Cocaine is the second most frequently used drug. It is hydrophobic and basic in nature. We have analyzed cocaine and related impurity on core-shell Coresep 100 mixed-mode column in reversed-phase cation-exchange modes. Core-shell mixed-mode chromatography offers a synergy of unique selectivity of mixed-mode stationary phases and high efficiency of core-shell particles. The method can be used for analysis of cocaine and other illegal drugs in various sample matrices. This method is compatible with major detection techniques including mass spectrometry.

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