MCPA

MCPA (2-Methyl-4-Chlorphenoxyacetic acid) ClC6H3(CH3)OCH2CO2H

Select Applications HPLC Analysis of Acidic Herbicides in Reverse-Phase Anion-Exchange Modes on Coresep SB Column HPLC Analysis of Herbicide MCPA on Coresep 100 Mixed-Mode Column Baseline HPLC Separation of 22 Acidic, Basic and Neutral Pesticides and Antibiotics on Coresep 100 Mixed-Mode Column HPLC Analysis of Herbicide MCPA on Heritage MA Mixed-Mode Column

HPLC Analysis of Acidic Herbicides in Reverse-Phase Anion-Exchange Modes on Coresep SB Column

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Conditions of Experiment

Column:	Coresep SB
Separation Modes:	reveresed-phase and anion-exchange
Column Dimenstions:	4.6x150 mm, 2.7 μm, 90A
Mobile Phase:	"ACN from 40% to 60% in 15 min, 5 min hold, 0.1% sulfuric acid
Detection:	275 nm
Sample:	0.3 mg/ml
Injection:	2 μL
Flow rate:	1 ml/min

Analytes

Class of compounds:	Aromatic acid, Aromatic compound, Fungicide, Herbicide, Organic acid, Pesticide
Nature of compounds:	Acidic, Basic, Hydrophilic, Hydrophobic, Neutral, Polar
Compounds:	Dalapon, 2,4-DB, Dinoseb, MCPA, Mecoprop, Dichlorprop, 2,4-D, Picloram, Dicamba, Silvex, 2,4,5-T, 3,5-DCBA, Pentachlorophenol (PCP)

HPLC Analysis of Herbicide MCPA on Coresep 100 Mixed-Mode Column

Application description

MCPA or (2-methyl-4-chlorophenoxyacetic acid is a powerful and selective phenoxy herbicide. It is used to control broadleaf weeds. It is also used in the chemical industry due to the ability to form conjugated complexes with metals. MCPA is hydrophobic and acidic and retains on Coresep 100 mixed-mode column by the combination of reversed-phase and anion-exclusion mechanisms. Retention time is controlled by the amount of ACN, buffer concentration and buffer pH. The method is suitable for analysis of various herbicides with LC/MS compatible conditions. Core-shell mixed-mode chromatography offers a synergy of unique selectivity of mixed-mode stationary phases and high efficiency of core-shell particles.

HPLC Analysis of Herbicide MCPA on Coresep 100 Mixed-Mode Column chromatogram

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Conditions of Experiment

Column:	Coresep 100
Separation Modes:	reversed-phase and anion-exclusion
Column Dimenstions:	3.0 x 100 mm
Mobile Phase:	ACN gradient from 15% to 60%, AmFm pH 3 from 30 mM to 80 mM, in 7 min
Detection:	UV 275 nm
Sample:	0.3 mg/ml
Injection:	1 uL
Flow rate:	0.7 mL/min

Analytes

Class of compounds:	Aromatic acid, Herbicide
Nature of compounds:	Acidic, Hydrophilic, Polar
Compounds:	MCPA

Baseline HPLC Separation of 22 Acidic, Basic and Neutral Pesticides and Antibiotics on Coresep 100 Mixed-Mode Column

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Conditions of Experiment

Column:	Coresep 100
Separation Modes:	reversed-phase, cation-exchange, anion-exclusion
Column Dimenstions:	3.0 x 100 mm
Mobile Phase:	ACN gradient from 15% to 60%, AmFm pH 3 from 30 mM to 80 mM, in 7 min, 3 min hold
Detection:	UV 275 nm
Sample:	0.1-0.3 mg/ml
Injection:	1 uL
Flow rate:	0.7 mL/min

Analytes

Class of compounds:	Amino acid, Antibiotic, Aromatic acid, Aromatic base, Aromatic compound, Drug, Fungicide, Herbicide, Insecticide, Pesticide, Pyridine
Nature of compounds:	Acidic, Basic, Hydrophilic, Hydrophobic, Neutral, Polar, Zwitterionic
Compounds:	Clopyralid (herbicide), Sulfadiazine, Sulfamethazine, Cefepime (antibiotic), Metribuzin, Bromacil, 2,4-D, MCPA, Thiacloprid (insecticide), 2,4,5-T, Diphenamid, Captan (fungicide), 2,4-DB, Triadimefon, Azinphos Ethyl, Diazinon, Chlorpyrifos Methyl, Phoxim, Teramisol (antibiotic), Benfluralin (herbicide), Dicofol, Hexachlorobenzene

HPLC Analysis of Herbicide MCPA on Heritage MA Mixed-Mode Column

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Conditions of Experiment

Column:	Heritage MA
Separation Modes:	reversed-phase and anion-exchange
Column Dimenstions:	4.6 x 50 mm
Mobile Phase:	60% ACN with 80 mM AmFm pH 3
Detection:	UV 275 nm
Sample:	0.3 mg/ml
Injection:	1 uL
Flow rate:	1 mL/min

Analytes

Class of compounds:	Aromatic acid, Herbicide
Nature of compounds:	Acidic, Hydrophilic, Polar
Compounds:	MCPA